{
  "$schema": "https://cdn.jsdelivr.net/npm/@genome-spy/app/dist/schema.json",

  "description": "Toy expression heatmap with five samples and gene-wise z-scores.",

  "data": {
    "values": [
      {
        "gene": "TP53",
        "S1.z": 1.8,
        "S2.z": 1.2,
        "S3.z": 0.7,
        "S4.z": -0.1,
        "S5.z": -0.8
      },
      {
        "gene": "BRCA1",
        "S1.z": -0.6,
        "S2.z": -0.9,
        "S3.z": -1.3,
        "S4.z": -1.0,
        "S5.z": -0.5
      },
      {
        "gene": "EGFR",
        "S1.z": 0.2,
        "S2.z": 0.6,
        "S3.z": 1.0,
        "S4.z": 1.5,
        "S5.z": 2.1
      },
      {
        "gene": "CDKN2A",
        "S1.z": -1.7,
        "S2.z": -1.3,
        "S3.z": -0.8,
        "S4.z": -0.2,
        "S5.z": 0.1
      },
      {
        "gene": "MYC",
        "S1.z": 0.4,
        "S2.z": 0.8,
        "S3.z": 1.1,
        "S4.z": 1.4,
        "S5.z": 1.0
      },
      {
        "gene": "PTEN",
        "S1.z": -0.3,
        "S2.z": -0.5,
        "S3.z": -0.7,
        "S4.z": -1.0,
        "S5.z": -1.4
      }
    ]
  },

  "transform": [
    {
      "type": "regexFold",
      "columnRegex": ["^(S[1-5])\\.z$"],
      "asKey": "sample",
      "asValue": ["zScore"]
    }
  ],

  "samples": {},

  "spec": {
    "name": "expression-zscores",

    "view": { "fill": "#f4f4f4" },
    "mark": {
      "type": "rect",
      "stroke": "white",
      "strokeWidth": 1
    },
    "encoding": {
      "sample": { "field": "sample" },
      "x": {
        "field": "gene",
        "type": "nominal",
        "scale": {
          "domain": ["TP53", "BRCA1", "EGFR", "CDKN2A", "MYC", "PTEN"]
        },
        "axis": {
          "title": "Gene",
          "grid": true
        }
      },
      "fill": {
        "field": "zScore",
        "type": "quantitative",
        "scale": {
          "domain": [-2.5, 0, 2.5],
          "range": ["#2166ac", "#f7f7f7", "#b2182b"],
          "clamp": true
        }
      }
    },

    "aggregateSamples": [
      {
        "name": "mean-zscores",
        "height": 70,
        "view": { "stroke": "lightgray" },
        "padding": { "bottom": 4 },
        "transform": [
          {
            "type": "aggregate",
            "groupby": ["gene"],
            "ops": ["mean"],
            "fields": ["zScore"],
            "as": ["meanZScore"]
          }
        ],
        "mark": {
          "type": "rect",
          "minWidth": 1,
          "stroke": "white",
          "strokeWidth": 1,
          "tooltip": null
        },
        "encoding": {
          "x": {
            "field": "gene",
            "type": "nominal"
          },
          "y": {
            "field": "meanZScore",
            "type": "quantitative",
            "axis": {
              "title": "Mean z-score",
              "grid": true
            },
            "scale": {
              "nice": true
            }
          },
          "y2": { "datum": 0, "type": "quantitative" },
          "fill": {
            "field": "meanZScore",
            "type": "quantitative",
            "scale": {
              "domain": [-2.5, 0, 2.5],
              "range": ["#2166ac", "#f7f7f7", "#b2182b"],
              "clamp": true
            }
          }
        }
      }
    ]
  }
}